aetheric.lifestyle 2

There are actually a bunch of natural MAOIs, but most of them are probably useless because of "their rapid metabolism, poor BBB penetration, and relatively low natural abundance":

https://www.bluelight.org/community/posts/16114386

… But scientists have experimented with making powerful synthetic derivatives of some of them! Are you familiar with Shulgin's work? ⇩

https://www.bluelight.org/community/posts/16350681

I tried the ℞ MAOI, Parnate, for a few months recently. –Never noticed a mood boost.

"It is noteworthy, contrary to popular current belief, that patients themselves frequently rate MAOIs as being more effective than “newer” drugs and as having fewer side effects.¹⁵ ⁻ ¹⁷" (doi: 10.1017/S1092852916000651)

"I think that is more of one doctor's opinion than patients'. Meta-analyses don't show MAOIs to be any more effective than other drugs and usually come with a warning that the studies are small and low quality."

https://x.com/HenryRunamucker/status/1953782002085187763

That being said, I did read a comment from one user who said it took 𝘮𝘰𝘯𝘵𝘩𝘴 for parnate to work.

"Irreversible" MAOIs are bad, though, because they kill REM sleep.

But yes, I have the same frustration: all the focus is on DMT. Check out @ancestralmagi, he's into harmalas big time. He's middle Eastern (i.e., Syrian rue). He's even curious about synthetic harmala derivatives and mentioned some Swiss research to me: https://www.instagram.com/p/DObvA1Yip2_/comments/

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