Endogenous DMT, lungs

DMT synthesis gene credibility check

DMT synthesis gene credibility check

Saved 2026-04-11 — original chat

You

Can we get a credible source for this?

"we do know that the gene involved in DMT synthesis is present in many organs, particularly lung." Rick Strassman, M.D. Quoted here: DMT and the Pineal: Fact or Fiction? Jon Hanna. 2010-06-03, 2017-12-14. https://erowid.org/chemicals/dmt/dmt_article2.shtml

Claude

Yes — Strassman's claim is well-supported by peer-reviewed literature. The key gene/enzyme is INMT (indolethylamine-N-methyltransferase), which catalyzes DMT synthesis. Here are credible sources:

Strongest sources:

  • Thompson et al. (1999) — the original molecular biology paper cloning human INMT and mapping its tissue distribution via Northern blot. INMT is widely expressed in the body, primarily in peripheral tissues such as the lungs, thyroid, and adrenal gland. [ 1 ] This is the foundational citation for Strassman's claim.
  • Barker et al. (2018) in Scientific Reports (Nature): High levels of INMT mRNA expression were found in rat kidney, lung, heart, and adrenal, consistent with earlier Northern blot analysis of human tissues. [ 2 ] Available at: https://www.nature.com/articles/s41598-019-45812-w
  • Frecska et al. / NIH/PMC review: Endogenous DMT has been confirmed in several tissues in humans, rats, and rabbits, including lung and brain. [ 3 ] (PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5924808/)

One nuance worth noting: More recent research has complicated the picture. A 2023 study found that brain and lung tissues from both wild-type and INMT-knockout rats show equal levels of tryptamine-dependent activity, but that the enzymatic products are neither NMT nor DMT [ 4 ] — suggesting INMT's exact role in DMT biosynthesis is still being worked out.

So the core claim — that the INMT gene is expressed prominently in the lung — is solid and peer-reviewed. The broader implication that the lung is a major source of endogenous DMT remains an active area of research.



[ 1 ] https://pmc.ncbi.nlm.nih.gov/articles/PMC5048497/
[ 2 ] https://www.nature.com/articles/s41598-019-45812-w
[ 3 ] https://pmc.ncbi.nlm.nih.gov/articles/PMC5924808/
[ 4 ] https://pubmed.ncbi.nlm.nih.gov/36609666/

Comments

Post a Comment

Popular posts from this blog

Tec2Future

Tec2Future manufactures colloidal minerals, monatomic minerals, and autonomous minerals. They make products from 29 different minerals, from what I can tell, all of which are listed at the bottom of this post. I gave Grok some of their literature and this is what it typed up ↓ Colloidal Elements Description : Colloidal elements are suspensions of microscopic particles of an element (e.g., gold, silver) in a liquid medium, typically double-distilled water or plant-based oil. These are produced using a proton resonance process, which excites the source material to create particles of consistent size and charge. The products are highly pure (99.995% for gold), available in concentrations like 55 ppm (parts per million) in water or 1,000 ppm in oil, and are packaged in blue glass bottles to protect from light. They are described as highly bioavailable, working primarily on the physical body to support overall health and vitality. The production emphasizes ethical standards, alignment with...
Read more

The Eyes Are Not Just Organs. Agata El Mrabet.

The Frequency Code: Unlocking the Hidden Power of Sound, Vibration, and Healing. Agata El Mrabet. 2025. Taken from https://www.instagram.com/yoga.agat/p/DLPUOb3tJRp “The eyes do not see. They resonate. They remember. They transmit.” — Scroll of the Lightbearers, Lyran Archives The Eyes Are Not Just Organs—They Are Frequency Gates We’ve been taught that the eyes are passive tools for sight. But the ancients—and advanced off-world civilizations—knew the deeper truth: The eyes are multidimensional frequency interfaces. They are not just perceivers. They are transmitters, receivers, and translators of light, emotion, memory, and soul codes. Behind every gaze is an energetic broadcast—a tone that others feel before they process what they see. That’s why: • A glance can melt someone’s defenses. • A stare can wound. You are tuning through the field of another’s being. And your own eyes hold your soul’s vibrational echo. 2. The Iris ...
Read more

Ibohuausca

This is a summary of  Micro Dose of Iboga and Caapi Combo  by  Claude Opus Reported Synergies: Detailed Analysis Core Subjective Synergy Reports Jorkest (the original experimenter) repeatedly describes a felt compatibility: "caapi and iboga seem like old friends" "every time i take caapi now it reminds me of iboga..and whenever i take iboga it reminds me of caapi" "i feel a real synergy between the two..if used in small doses i feel its completely safe" Bancopuma offers the phenomenological comparison you flagged: "for me a flood dose does in some ways resemble a very large dose of caapi alone. In fact, my last ayahuasca experience was one of my most powerful, and at the peak, it felt like I was back in the Iboga trance! I was amazed at the similarities, and I got the distinct impression that this was the caapi's touch." He concludes: "I think as long as one treads carefully, these actually might be quite compatible med...
Read more